Lisa

"You'll do the right thing. I know it. You're only five, but you're very smart. Sometimes we take a leap. Be brave. You can do it... I love you, Sōsuke.
 * —Lisa to her son"

Lisa is the mother of Sōsuke and the wife of Kōichi in Ponyo.

Trivia

 * Lisa is one of the few characters of Studio Ghibli films to have a name of Western origin and not Asian, and oddly has a Western name, despite the fact that she is Japanese.